File Name: oxidative stress and diabetic complications writer.zip
Diabetes: Oxidative Stress and Dietary Antioxidants, Second Edition, builds on the success of the first edition, covering updated research on the science of oxidative stress in diabetes and the potentially therapeutic usage of natural antioxidants in the diet and food matrix. The processes within the science of oxidative stress are not described in isolation, but rather in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses.
Author s : Ludovica Piconi , Michael A. DOI : In diabetes oxidative stress plays a key role in the pathogenesis of vascular complications, and an early step of such damage is considered the development of an endothelial dysfunction. Hyperglycemia directly promotes an endothelial dysfunction inducing process of overproduction of superoxide and consequently peroxynitrite that damages DNA and activates the nuclear enzyme poly ADP-ribose polymerase. New, low molecular mass compounds that act as SOD or catalase mimetics or L-propionyl-carnitine and lipoic acid, that work as intracellular superoxide scavengers, improving mitochondrial function and reducing DNA damage, may be good candidates for such strategy, and preliminary studies support this hypothesis. It is now evident that, statins, ACE inhibitors, AT-1 blockers, calcium channel blockers and thiazolinediones have a strong intracellular antioxidant activity, and it has been suggested that many of their beneficial ancillary effects are due to this property. This preventive activity against oxidative stress generation can justify a large utilization and association of this compounds for preventing complications in diabetic patients where antioxidant defences have been shown to be defective.
Accumulating evidence indicates the occurrence and development of diabetic complications relates to not only constant high plasma glucose, but also glucose fluctuations which affect various kinds of molecular mechanisms in various target cells and tissues. A deeper understanding of glucose-fluctuation-related molecular mechanisms in the development of diabetic complications may enable more potential target therapies in future. Diabetes is a chronic metabolic disorder and a threat to human health in the world 1. In the past decades, it has been verified in both clinical and experimental studies that glucose fluctuations are more harmful than in a comparative state of constant hyperglycemia 2. Recently, increasing levels of experimental researches have investigated the relationship between glucose fluctuations and diabetic complications 3.
Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus T2DM and this appears to underlie the development of cardiovascular disease, T2DM and diabetic complications. Core tip: Oxidative stress is underling in the development of cardiovascular disease, type 2 diabetes mellitus T2DM and diabetic complications. Aerobic life uses oxygen to oxidize metabolism food substrates carbon- and hydrogen-rich to obtain the heat energy and chemical essential for life. When we oxidize molecules with oxygen, the oxygen molecule itself becomes reduced and forms intermediates. In eukaryotic cells, reactive oxygen species ROS are always produced as the consequence of regular physiological metabolism [ 1 ]. These ROS pro-oxidants productions are counter-balanced by cellular antioxidant defense mechanisms in the normal physiological conditions.
Oxidative stress is suggested to be the crucial factor in diabetes mellitus type 2 DM2 pathogenesis and in the development of diabetic complications. Patients with DM2 may be more susceptible to infections due to hyperglycaemia-induced virulence of various microorganisms. Blood and saliva were collected from patients with DM2. Spectrophotometric methods were implemented to determine serum GPx and SOD activity with the use of diagnostic kits produced by Randox Laboratories. In patients with DM2 history longer than 10 years as well as in DM2 patients with obesity, antioxidant enzymes activity was decreased. Determination of examined parameters may be useful in diabetic patients with EBV infection and could be important prognostic factor.
PDF | Despite the availability of various antidiabetic drugs, diabetes mellitus (DM) remains one A Review on Oxidative Stress, Diabetic Complications, and the Roles of Honey Polyphenols Academic Editor: Yueliang Zhao.
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects of insulin action, insulin secretion or both [ 1 ]. Diabetes has taken place as one of the most important diseases worldwide, reaching epidemic proportions. Hyperglycemia in the course of diabetes usually leads to the development of microvascular complications, and diabetic patients are more prone to accelerated atherosclerotic macrovascular disease. These complications account for premature mortality and most of the social and economical burden in the long term of diabetes [ 3 ].
International Journal of Diabetes and Clinical Research is a global peer reviewed open access journal that emphasis on the different aspects of clinical diabetes. It highlights the investigative reports focusing on areas such as the pathogenesis of diabetes and its complications, normal and pathologic pancreatic islet function and intermediary metabolism, pharmacological mechanisms of drug and hormone action, and biochemical and molecular aspects of normal and abnormal biological processes. Clinical Diabetes acts as platform for the diabetes health care practitioners and clinicians to represent their Original Work, Reviews, Commentaries, Shorts Communications, Letters, Oral Presentations and Case Studies. International Journal of Diabetes and Clinical Research ensures the faster publication of high quality articles with the support of its eminent Editorial board members.
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Oxidative stress plays a pivotal role in the development of diabetes complications, In addition, diabetic cardiomyopathy is a major diabetic complication. This is a PDF file of an unedited manuscript that has been accepted for publication. Writing Team for the Diabetes Control and Complications Trial/Epidemiology of.Reply
Academic Editor: Yueliang Zhao. Received The Role of Insulin Resistance in Diabetic Complications. Insulin The Role of Oxidative Stress in Diabetic Complications. Although PDF Download Citation Citation. Download.Reply
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