topical drug bioavailability bioequivalence and penetration pdf

Topical drug bioavailability bioequivalence and penetration pdf

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Table of contents

Introduction

Topical Drug Bioavailability Bioequivalence And Penetration Books

Table of contents

Ansermet, CH Geneva 4, Switzerland. Mounier 73, Brussels, Belgium. This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of model-based predictions, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described.

Introduction

Objective: The aim of the study was to formulate Clobetasol propionate into a gel formulation using carbopol, Hydroxypropyl methylcellulose K4M, sodium alginate, Carboxymethylcellulose Sodium as gelling agents. Clobetasol propionate was used in the concentration of 0. Propylene glycol served as a co-solvent for drug. Triethanolamine was used to neutralize carbopol gel systems. Methyl paraben and propyl paraben were used as preservatives. A total of twenty two formulations were prepared with 6 formulation containing combination of various gelling agents.

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Topical Drug Bioavailability Bioequivalence And Penetration Books

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