emerging therapeutic potential of graviola and its constituents in cancers pdf

Emerging therapeutic potential of graviola and its constituents in cancers pdf

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Published: 30.04.2021

Introduction

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Introduction

Introduction: Malignancies constitute a wide variety of disorders having high mortality and morbidity rates. Current protocols for management include surgical intervention, chemotherapy, and radiation which possess numerous adverse effects. Many phytochemicals are available with anticancer properties similar to anticancer drugs.

Soursop is a fruit that may help fight cancer, but human studies are lacking to prove this. It also has some safety concerns. This article looks at the potential benefits of soursop, including how it might help fight cancer.

Introduction

Cancer remains a leading cause of death in the USA and around the world. Although the current synthetic inhibitors used in targeted therapies have improved patient prognosis, toxicity and development of resistance to these agents remain a challenge. Plant-derived natural products and their derivatives have historically been used to treat various diseases, including cancer. Several leading chemotherapeutic agents are directly or indirectly based on botanical natural products. Beyond these important drugs, however, a number of crude herbal or botanical preparations have also shown promising utility for cancer and other disorders. One such natural resource is derived from certain plants of the family Annonaceae, which are widely distributed in tropical and subtropical regions. Among the best known of these is Annona muricata, also known as soursop, graviola or guanabana.

Cancer remains a leading cause of death in the USA and around the world. Although the current synthetic inhibitors used in targeted therapies have improved patient prognosis, toxicity and development of resistance to these agents remain a challenge. Plant-derived natural products and their derivatives have historically been used to treat various diseases, including cancer. Several leading chemotherapeutic agents are directly or indirectly based on botanical natural products. Beyond these important drugs, however, a number of crude herbal or botanical preparations have also shown promising utility for cancer and other disorders.

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Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Received 30 August Published 4 December Volume Pages — Review by Single anonymous peer review. Methods: The triple-negative human breast cancer BT cells were used.


Request PDF | Emerging Therapeutic Potential of Graviola and its Constituents in Cancers | Cancer remains a leading cause of death in the United States and.


Introduction

Phytochemical complexity of plant extracts may offer health-promoting benefits including chemotherapeutic and chemopreventive effects. Isolation of 'most-active fraction' or single constituents from whole extracts may not only compromise the therapeutic efficacy but also render toxicity, thus emphasizing the importance of preserving the natural composition of whole extracts. The leaves of Annona muricata, commonly known as Graviola, are known to be rich in flavonoids, isoquinoline alkaloids and annonaceous acetogenins. In vivo pharmacokinetics and in vitro absorption kinetics of flavonoids revealed enhanced bioavailability of rutin in FEF compared to GLE.

Can soursop help fight cancer?

Pancreatic tumors are resistant to conventional chemotherapies.

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